Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period.

摘要: Abstract Newborn mice were administered Fe2+ (iron succinate: 7.5 mg/kg, b.wt) on either Days 3–5, 10–12 or 19–21, vehicle (saline) at the same times, postnatally. Spontaneous motor behaviour and radial arm maze learning tested age of 3 months. It was found that treated with during postnatal markedly hypokinetic 1st 20-min test period hyperkinetic 3rd final period. These showed an almost complete lack habituation spontaneous activity parameters to chambers. In maze, treatment group evidenced significantly both more errors in choices longer latencies acquire all eight pellets; these also a severe trial-to-trial retention deficit as indexed by quotients. behavioural deficits observed animals but effects less pronounced, indicating higher susceptibility brain for Fe2+-induced damage postpartum. Treatment 19–21 did not induce alterations comparison its respective control (vehicle) group. Analysis total iron content indicated (μg/g) accumulation basal ganglia, frontal cortex, from 3–5 (7.5 mg/kg) groups. The contribution overload immediate later functional seems implicate symptoms Parkinsonism kinetics uptake regional distribution this critical development awaits elucidation.