Cross-metathesis-based approaches to heteroaromatics: combining catalysts for furan formation.

摘要: Ring-closing olefin metathesis (RCM) is an effective method for the formation of cyclic alkenes (1). Recently, aromatization RCM products has emerged as a topic intensive investigation (2). In this context, variety regiocontrolled protocols have been developed synthesis diverse heteroaromatic compounds, such pyridines, pyridazines, pyrroles, quinolines, and furans all reported approaches, key strategic consideration relates to requirement intermolecular fragment union in advance event. Strategies based on use alkene metathesis, termed cross-metathesis, would potentially streamline access aromatic structures by uniting steps coupling formation. However, cross-metathesis heterocycles prohibited fact that trans-alkene predominate (3, 4), which are unsuitable cycloaromatization. A report Donohoe Bower (3) issue …