Glycaemic variability using continuous glucose monitoring and endothelial function in the metabolic syndrome and in Type 2 diabetes.

摘要: Diabet. Med. 27, 872–878 (2010) Abstract Aims  Subjects who are at increased risk of developing diabetes may have glycaemic variability associated with endothelial dysfunction and possibly subclinical atherosclerosis, which lead to cardiovascular observed the time diagnosis. To investigate this hypothesis, we measured function, carotid intima-media thickness using 48-h continuous subcutaneous glucose monitoring in 3 groups overweight or obese subjects – those without metabolic syndrome, syndrome newly diagnosed Type 2 diabetes. Methods  Consecutive subjects, aged 30–65 years a body mass index ≥ 25 kg/m2 were recruited. Patients classified as syndrome,or DM. Glycaemic was calculated terms coefficient variation. Endothelial function brachial artery flow-mediated dilation. Results  We identified 75 subjects. Mean flow mediated dilation decreased (P < 0.001) (P < 0.05) across groups. Flow predictors included mean values (β = –0.022; P < 0.005) variation (β = –0.10; P = 0.01). Carotid age (β = 0.009; P < 0.001) (β = –0.014; P = 0.076). re-stratified according cut-offs for glycaemia demonstrated that high but low had similar variation. Conclusions  This study suggests influences even non-diabetic Such explain patients prior overt