Eosinophilic Esophagitis and Gastroenteritis.

摘要: Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis (EoE) when the eosinophilia is limited to esophagus or gastritis (EG) if it gastric tract, colitis (EC) colon, and gastroenteritis (EGE) involves one more parts of tract. EoE by far most common EGID. It a well-defined chronic atopic due T helper type 2 (Th2) inflammation triggered often food allergens. diagnosis done an esophageal biopsy shows at least 15 eosinophils per high power field (eos/hpf). Globally accepted long-term therapies for are use swallowed inhaled steroids antigen avoidance. The treatment not only control symptoms but also prevent complications such stricture impaction. EGE cause non-specific (GI) diagnosed esophagogastroduodenoscopy (EGD)/colonoscopy show in GI They rare diseases with unclear pathogenesis, they poorly defined terms diagnostic criteria treatment. Before initiating any EGE, imperative conduct differential exclude other causes hypereosinophilia localization. responsive therapy there no commonly EG has many characteristics similar EoE, including fact that allergen-driven Th2 inflammation; transcriptome analysis however systemic different gene signature than EoE. EC benign form delayed allergy infant instead difficult-to-treat severe inflammatory condition older children adults. latter groups manifestation drug autoimmune disease. Overall EC, exclusion until have been excluded.