Uptake and distribution of 14C during and following inhalation exposure to radioactive toluene diisocyanate
作者： A.L. Kennedy , M.F. Stock , Y. Alarie , W.E. Brown
DOI: 10.1016/0041-008X(89)90314-1
关键词:
摘要: Abstract Inhalation of toluene diisocyanate (TDI) results in toxic responses ranging from pulmonary irritation to immunological sensitization. The use radioactively labeled isocyanate has made it possible follow the initial uptake compound into bloodstream independent final fate isocyanate. This study shows that rate blood is linear during exposure concentrations 0.00005 0.146 ppm and continues increase slightly postexposure. It also demonstrates radioactivity clears a level corresponding approximately 100 n m concentration tolyl group after 72 hr persists at nanomolar even 2 weeks following exposure. similar response previously reported by this for methyl 14 C function TDI when expressed either as (ppm) or multiplied duration (ppm · hr). discussed comparison with both hr. Finally, inclusion data on indicates arterial concentration, structure.
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