Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas

摘要: Abstract Proteomic analysis was performed to compare the effects of Arsenic (As), seawater acidification (Low pH) and combination both stressors pH + As) on Crassostrea angulata gigas juveniles in context global environmental change. This study aimed elucidate if two closely related species respond similarly these stressors, considering single combined exposures, infer simultaneous exposure induced a differentiated response. Identification most important differentially expressed proteins between conditions revealed marked differences response each towards evidencing species-related experimental condition. Moreover, protein alterations observed were substantially different from those exposures. Identified their putative biological functions an array modes action Among important, involved cellular structure (Actin, Atlastin, Severin, Gelsolin, Coronin) extracellular matrix modulation (Ependymin, Tight junction ZO-1, Neprilysin) strongly regulated, although species. Data also regarding metabolic capacity (ATP β, Enolase, Aconitate hydratase) oxidative stress (Aldehyde dehydrogenase, Lactoylglutathione, Retinal dehydrogenase) species, which depended or illustrating oyster presence multiple stressors. Interestingly, piRNA abundance C. suggested genome reconfiguration likely mode adaptive evolution mechanisms previously unknown requires further investigation. The present findings provide deeper insight into complexity responses at proteome level, capacities endure abiotic changes, with relevance ecophysiological fitness competitive advantages changing environment.