PANDAS With Catatonia: A Case Report. Therapeutic Response to Lorazepam and Plasmapheresis
作者： Josephine Elia , Mary Lynn Dell , David F. Friedman , Robert A. Zimmerman , Naomi Balamuth
DOI: 10.1097/01.CHI.0000179056.54419.5E
关键词:
摘要: ABSTRACT This is a report of an 11-year-old, prepubertal boy with acute-onset urinary urgency and frequency, obsessions compulsions related to urination, severe mood lability, inattention, impulsivity, hyperactivity, intermittent periods immobilization. Fever, cough, otitis, sinusitis preceded neuropsychiatric symptoms. Antistreptolysin O DNAse B antibody titers were elevated, magnetic resonance imaging revealed bilateral diffuse caudate nuclei swelling. Plasmapheresis resulted in significant rapid clinical improvement obsessive-compulsive disorder symptoms simultaneous decrease basal ganglia swelling, consistent immune-mediated pathophysiological process involving group A β-hemolytic streptococci. Hyperactivity, inattention improved lorazepam, suggesting that the attention-deficit/hyperactivity could be manifestations catatonia.
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