Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.

摘要: Abstract Drosophila females that lack Toll gene activity produce dorsalized embryos, in which all embryonic cells behave like the dorsal of wild-type embryo. Injection cytoplasm into young − embryos restores their ability to a normal dorsal-ventral pattern position-dependent manner. No matter where is injected relative axis egg shell, position defines ventralmost part rescued pattern. Although injection mutants at six other dorsal-group loci also lateral and ventral structures, only any residual polarity. Experiments suggest product normally regulated by genes function provide source for morphogen gradient