Adipose afferent reflex: sympathetic activation and obesity hypertension
作者： X.-Q. Xiong , W.-W. Chen , G.-Q. Zhu
DOI: 10.1111/APHA.12182
关键词:
摘要: Excessive sympathetic activity contributes to the pathogenesis of hypertension and progression related organ damage. Adipose afferent reflex (AAR) is a sympatho-excitatory that from white adipose tissue (WAT) increases outflow blood pressure. Hypothalamic paraventricular nucleus (PVN or PVH) one central sites in control AAR, ionotropic glutamate receptors mediate AAR. The AAR enhanced obesity hypertension. Enhanced WAT contribute excessive activation obesity. Blockage attenuates Leptin may be sensors for involved This review focuses on neuroanatomical basis physiological functions important role
sci-hub.se 参考文章(106)
Janet. Kirtland, Michael I. Gurr, Adipose tissue cellularity: A review. 2. The relationship between cellularity and obesity International Journal of Obesity. ,vol. 3, pp. 15- 55 ,(1979)
J. H. Coote, A role for the paraventricular nucleus of the hypothalamus in the autonomic control of heart and kidney Experimental Physiology. ,vol. 90, pp. 169- 173 ,(2005) , 10.1113/EXPPHYSIOL.2004.029041
Guido Grassi, Gino Seravalle, Fosca Quarti-Trevano, The 'neuroadrenergic hypothesis' in hypertension: current evidence. Experimental Physiology. ,vol. 95, pp. 581- 586 ,(2010) , 10.1113/EXPPHYSIOL.2009.047381
Yao Xu, Qing Gao, Xian-Bing Gan, Lei Chen, Lei Zhang, Guo-Qing Zhu, Xing-Ya Gao, Endogenous hydrogen peroxide in paraventricular nucleus mediates sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Experimental Physiology. ,vol. 96, pp. 1282- 1292 ,(2011) , 10.1113/EXPPHYSIOL.2011.059733
Noreen F. Rossi, Maria Maliszewska-Scislo, Haiping Chen, Stephen M. Black, Shruti Sharma, Ruslan Ravikov, Robert A. Augustyniak, Neuronal nitric oxide synthase within paraventricular nucleus: blood pressure and baroreflex in two-kidney, one-clip hypertensive rats. Experimental Physiology. ,vol. 95, pp. 845- 857 ,(2010) , 10.1113/EXPPHYSIOL.2009.051789
M. Tesauro, C. Cardillo, Obesity, blood vessels and metabolic syndrome. Acta Physiologica. ,vol. 203, pp. 279- 286 ,(2011) , 10.1111/J.1748-1716.2011.02290.X
P Trayhurn, J S Duncan, D V Rayner, Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system Biochemical Journal. ,vol. 311, pp. 729- 733 ,(1995) , 10.1042/BJ3110729
M. Benito, Tissue specificity on insulin action and resistance: past to recent mechanisms. Acta Physiologica. ,vol. 201, pp. 297- 312 ,(2011) , 10.1111/J.1748-1716.2010.02201.X
Ming-Kui Zhong, Yang-Can Duan, Ai-Dong Chen, Bo Xu, Xing-Ya Gao, Wei De, Guo-Qing Zhu, Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats Experimental Physiology. ,vol. 93, pp. 746- 753 ,(2008) , 10.1113/EXPPHYSIOL.2007.041632
GEORGE A. BRAY, YOSHIKI NISHIZAWA, Ventromedial hypothalamus modulates fat mobilisation during fasting Nature. ,vol. 274, pp. 900- 902 ,(1978) , 10.1038/274900A0