Treatment-induced hearing loss and adult social outcomes in survivors of childhood CNS and non-CNS solid tumors: Results from the St. Jude Lifetime Cohort Study.

摘要: BACKGROUND Survivors of childhood cancer who are treated with platinum-based chemotherapy and/or cranial radiation at risk treatment-induced hearing loss. However, the effects such loss on adult social attainment have not been well elucidated. METHODS Adult survivors pediatric central nervous system (CNS) solid tumors (180 survivors) and non-CNS (226 were potentially ototoxic therapy completed audiologic evaluations questionnaires assessing their perception functioning (ie, independent living, marriage, employment). Audiograms graded Chang ototoxicity grading scale. Analyses stratified by tumor type CNS vs non-CNS). Multivariable logistic regression models conducted adjustment for age; sex; chronic health conditions; and, group, IQ. Adjusted odds ratios (ORs) 95% confidence intervals (95% CIs) reported. RESULTS Serious (that requiring a aid or deafness) was detected in 36% 39% tumors. Serious associated an increased perceived negative impact ≥1 areas (survivors tumors: OR, 1.83 [95% CI, 1.00-3.34]). Among tumors, serious 2-fold nonindependent living (OR, 2.19; 1.19-4.04) unemployment graduating from high school 1.85; 1.00-3.34). CONCLUSIONS A substantial proportion Treatment-induced found to be reduced attainment, both actual, this study sample. Cancer 2015. © 2015 American Society.