Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

A Pession, M Derenzini, L Montanaro, R L Ochs, V Sirri, D Trerè, Nucleolar function and size in cancer cells. American Journal of Pathology. ,vol. 152, pp. 1291- 1297 ,(1998)

Yves Pommier, Juana M. Barcelo, V. Ashutosh Rao, Olivier Sordet, Andrew G. Jobson, Laurent Thibaut, Ze‐Hong Miao, Jennifer A. Seiler, Hongliang Zhang, Christophe Marchand, Keli Agama, John L. Nitiss, Christophe Redon, Repair of topoisomerase I-mediated DNA damage. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 81, pp. 179- 229 ,(2006) , 10.1016/S0079-6603(06)81005-6

F Scala, E Brighenti, M Govoni, E Imbrogno, F Fornari, D Treré, L Montanaro, M Derenzini, Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene. ,vol. 35, pp. 977- 989 ,(2016) , 10.1038/ONC.2015.147

Karen I. Zeller, Timothy J. Haggerty, John F. Barrett, Qingbin Guo, Diane R. Wonsey, Chi V. Dang, Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation Journal of Biological Chemistry. ,vol. 276, pp. 48285- 48291 ,(2001) , 10.1074/JBC.M108506200

B. Thomsen, S. Mollerup, B. J. Bonven, R. Frank, H. Blöcker, O. F. Nielsen, O. Westergaard, Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin. The EMBO Journal. ,vol. 6, pp. 1817- 1823 ,(1987) , 10.1002/J.1460-2075.1987.TB02436.X

M Kermekchiev, J L Workman, C S Pikaard, Nucleosome binding by the polymerase I transactivator upstream binding factor displaces linker histone H1. Molecular and Cellular Biology. ,vol. 17, pp. 5833- 5842 ,(1997) , 10.1128/MCB.17.10.5833

Jackie Russell, Joost CBM Zomerdijk, None, The RNA polymerase I transcription machinery. Biochemical Society Symposia. ,vol. 73, pp. 203- 216 ,(2006) , 10.1042/BSS0730203

Daniela Rhodes, Hans J. Lipps, G-quadruplexes and their regulatory roles in biology. Nucleic Acids Research. ,vol. 43, pp. 8627- 8637 ,(2015) , 10.1093/NAR/GKV862

Nourdine Hamdane, Chelsea Herdman, Jean-Clement Mars, Victor Stefanovsky, Michel G. Tremblay, Tom Moss, Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells Oncotarget. ,vol. 6, pp. 27519- 27536 ,(2015) , 10.18632/ONCOTARGET.4823

Sandeep S. Negi, Patrick Brown, rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. Oncotarget. ,vol. 6, pp. 18094- 18104 ,(2015) , 10.18632/ONCOTARGET.4093