Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.

摘要: Abstract Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD), and amyotrophic lateral sclerosis (ALS) lack robust diagnostics prognostic biomarkers. Metabolomics is a postgenomics field that offers fresh insights for biomarkers of common complex well rare diseases. Using data on metabolite-disease associations published in the previous decade (2006–2016) PubMed, ScienceDirect, Scopus, Web Science, we identified 101 metabolites putative these three neurodegenerative Notably, uric acid, choline, creatine, L-glutamine, alanine, creatinine, N-acetyl-L-aspartate were shared metabolite signatures among The disease-metabolite-pathway pointed out importance membrane transport (through ATP binding cassette transporters), particularly arginine proline amino acids all When disease-specific metabolic pathways queried by using ...