Poly(2-oxazoline)-based magnetic hydrogels: Synthesis, performance and cytotoxicity.

摘要: Abstract Research on the subject of smart biomaterials has become a cornerstone tissue engineering and regenerative medicine. Herein, authors report developing magnetic hydrogels that combine high biocompatibility remarkable activity in fields. We fabricated based poly(2-ethyl-2-oxazoline) (POx) via living ring-opening cationic polymerization with in-situ embedding carbonyl iron (CI) particles. Investigation was made as to effect exerted by concentration CI magnetic, viscoelastic/magnetorheological properties, degree equilibrium swelling, cytotoxicity. The exhibited an open pore structure, evidenced computed tomography (CT) imaging. Susceptibility measurements revealed concentration-dependent field-induced particle restructuration indicating elongation/contraction material, thereby determining potential for magneto-mechanical stimulation cells. POx-based were amphiphilic character, showing decrease their capability hold liquid alongside increase concentration. Viscoelastic suggested interaction occurred between particles matrix inconsistency experimental storage modulus Krieger–Dougherty model. synthesized materials excellent toward 3T3 fibroblast cell line tests extract toxicity direct contact cytotoxicity (ISO standards). unique combination properties material - could prove favorable fields such biomedicine biomechanics.