Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.
作者： Nobuyuki Kobayashi , Shunichiro Shinagawa , Tomoyuki Nagata , Kazuya Shimada , Nobuto Shibata
DOI: 10.1371/JOURNAL.PONE.0168816
关键词:
摘要: In order to conduct early therapeutic interventions for Alzheimer's disease (AD), convenient, diagnosis markers are required. We previously reported that changes in DNA methylation levels were associated with amnestic mild cognitive impairment (aMCI) and AD. As the results suggested COASY SPINT1 gene promoter regions, present study we examined these regions normal controls (NCs, n = 30), aMCI subjects (n 28) AD 30) using methylation-sensitive high resolution melting (MS-HRM) analysis. The indicated two was significantly increased as compared NCs (P < 0.0001, P ANOVA). Further analysis region particular could be a sensitivity, specificity biomarker (COASY: sensitivity 96.6%, 96.7%; SPINT1: 63.8%, 83.3%). CDR Scale Sum of Boxes (CDR-SB), an indicator dementia severity. region, negatively age elevated positive antibodies Herpes simplex virus type 1 (HSV-1). These findings influenced by various factors. conclusion, considered potentially convenient useful aMCI.
harvard.edu
sci-hub.se 参考文章(40)
B Reisberg, A Georgotas, J Borenstein, E Franssen, S H Ferris, S P Salob, Behavioral symptoms in Alzheimer's disease: Phenomenology and treatment. The Journal of Clinical Psychiatry. ,vol. 48, pp. 9- 15 ,(1987)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
David A. Bennett, Lei Yu, Jingyun Yang, Gyan P. Srivastava, Cristin Aubin, Philip L. De Jager, Epigenomics of Alzheimer's disease Translational Research. ,vol. 165, pp. 200- 220 ,(2015) , 10.1016/J.TRSL.2014.05.006
Donald R Royall, The FAB A frontal assessment battery at bedside Neurology. ,vol. 55, pp. 1621- 1626 ,(2000) , 10.1212/WNL.55.11.1621
Joseph H. Lee, Susan Gurney, Deborah Pang, Alexis Temkin, Naeun Park, Sarah C. Janicki, Warren B. Zigman, Wayne Silverman, Benjamin Tycko, Nicole Schupf, Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer's Disease in Women with Down Syndrome. Current Gerontology and Geriatrics Research. ,vol. 2012, pp. 361218- 361218 ,(2012) , 10.1155/2012/361218
Katie Lunnon, Rebecca Smith, Eilis Hannon, Philip L De Jager, Gyan Srivastava, Manuela Volta, Claire Troakes, Safa Al-Sarraj, Joe Burrage, Ruby Macdonald, Daniel Condliffe, Lorna W Harries, Pavel Katsel, Vahram Haroutunian, Zachary Kaminsky, Catharine Joachim, John Powell, Simon Lovestone, David A Bennett, Leonard C Schalkwyk, Jonathan Mill, Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease Nature Neuroscience. ,vol. 17, pp. 1164- 1170 ,(2014) , 10.1038/NN.3782
R. Bartus, R. Dean, B Beer, A. Lippa, The cholinergic hypothesis of geriatric memory dysfunction Science. ,vol. 217, pp. 408- 414 ,(1982) , 10.1126/SCIENCE.7046051
Jae-Min Kim, Robert Stewart, Hee-Ju Kang, Seon-Young Kim, Sung-Wan Kim, Il-Seon Shin, Man-Seok Park, Hye-Ran Kim, Myung-Geun Shin, Ki-Hyun Cho, Jin-Sang Yoon, A Longitudinal Study of BDNF Promoter Methylation and Genotype With Poststroke Depression Journal of Affective Disorders. ,vol. 149, pp. 93- 99 ,(2013) , 10.1016/J.JAD.2013.01.008
Hiroaki Kataoka, Takeshi Shimomura, Toshiya Kawaguchi, Ryouichi Hamasuna, Hiroshi Itoh, Naomi Kitamura, Keiji Miyazawa, Masashi Koono, Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. Journal of Biological Chemistry. ,vol. 275, pp. 40453- 40462 ,(2000) , 10.1074/JBC.M006412200
M. Katan, Y. P. Moon, M. C. Paik, R. L. Sacco, C. B. Wright, M. S. V. Elkind, Infectious burden and cognitive function The Northern Manhattan Study Neurology. ,vol. 80, pp. 1209- 1215 ,(2013) , 10.1212/WNL.0B013E3182896E79