Lassa Fever

摘要: Abstract In a study of Lassa fever in Sierra Leone, West Africa, we identified two variables associated with high risk death, and evaluated the efficacy ribavirin virus-convalescent plasma for treatment fever. A serum aspartate aminotransferase level greater than or equal to 150 IU per liter at time hospital admission was case-fatality rate 55 percent (33 60). Patients same factor who were treated 10 days intravenous ribavirin, begun within first 6 after onset fever, had 5 (1 20) (P = 0.0002 by Fisher's exact test). whose began seven more 26 (11 43) 0.01). Viremia levels 10(3.6) TCID50 milliliter on 76 (35 46). this six 9 11) 0.006), whereas those illness fatality 47 (9 19) 0.035). Oral also effective patients death. Lassa-convalescent did not significantly reduce mortality any high-risk groups. We conclude that is it should be used point illness, as well postexposure prophylaxis.