Transferrin-Modified Nanoliposome Codelivery Strategies for Enhancing the Cancer Therapy

摘要: Abstract Chemotherapy remains one of the most effective treatments for many cancers in a clinic. At present, various targets have been used to modify PEGylated liposomes doxorubicin (Dox) delivery, but antitumor effect Dox is not satisfactory. Therefore, combination chemotherapeutics has considered as promising method improve tumor treatment. These years, RAF/MEK/ERK-mediated cell signaling pathway discovered inhibit growth tumors. Thus, Sorafenib tosylate (Sor) was this study, which directly inhibited proliferation through blocking and indirectly angiogenesis by VEGFR PDGF. In article, we develop “combination delivery system” deliver hydrophobic drug phospholipid bilayer hydrophilic inner cores enhancing effect. Moreover, in vitro experiments verified whether physicochemical properties carriers were stable transferrin-modified displayed highest uptake. The results in vivo showed that codelivery system more effectively than monotherapy. Overall, delivering drugs simultaneously may offer novel strategy breast cancer treatment provide reference possibility clinical usage.