Growth of Human Tumor Xenografts Implanted under the Renal Capsule of Normal Immunocompetent Mice

摘要: The subrenal capsule technique proved effective in demonstrating that the growth of human tumors normal, immunocompetent animals for 6 days was quantifiable ocular micrometer units. Positive demonstrable not only with had been established serial transplantation athymic nude mouse hosts, but also primary surgical explants. Growth rates transplantation-established xenograft systems were similar whether implanted or normal indicating 6-day time-frame successfully evades inhibitory effects immunologic origin. Immunosuppression a single dose cyclophosphamide did appear to affect rate, permitted grow larger extending time reach peak size. Significantly, xenografts explants showed positive more frequently (82%) animal than 11 (30%) immunodeficient mouse.