Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy.

摘要: Purpose: The association between autism spectrum disorders (ASDs) and prenatal anticonvulsant exposure is increasingly investigated, but comprehensive, blinded assessment using a validated instrument for within well-characterized prospective cohort has not been conducted. Thus, existing studies may represent an underestimate of the true risk. Herein we present study in children exposed to anticonvulsants during pregnancy, with all assessments conducted by examiners who were drug-exposure status. Methods: Participants 105 Australian aged 6–8 years recruited via Pregnancy Register Women on Antiepileptic Medication. Maternal epilepsy, medical history data obtained prospectively. Autism traits assessed Childhood Rating Scale (CARS). Results: Eleven (10.5%) had elevated CARS scores. Two valproate monotherapy (2/26; 7.7%), two carbamazepine (2/34; 5.9%), seven polytherapy (7/15; 46.7%). Linear regression analysis showed that mean dose pregnancy was significant predictor scores after controlling polytherapy, dose, folic acid use, seizures tobacco marijuana maternal intelligence quotient (IQ), socioeconomic First trimester supplementation use also predictors Significance: Using direct our study, found rate across sample. most important determinant autistic higher doses sodium exposure. women become pregnant now generally avoided; however, there are insufficient regarding risk ASD low-dose valproate. If this no greater than other antiepileptic drugs (AED)s, it enable genetic generalized epilepsy retain optimal seizure control as well minimize harm their unborn child.