The teratogenic risk of antiepileptic drug polytherapy
作者： Frank J. E. Vajda , Alison A. Hitchcock , Janet Graham , Terence J. O’Brien , Cecilie M. Lander
DOI: 10.1111/J.1528-1167.2009.02336.X
关键词:
摘要: Purpose: To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. Methods: Statistical analysis rate exposure data from Australian Register Antiepileptic Drugs in Pregnancy, literature. Results: The calculated relative risk (RR) value for AED compared monotherapy was below 1.0 only 3 14 literature publications. In register, at 1 year postnatally there were malformations 5.32% 282 pregnancies, 7.84% 791 an RR 0.68 [95% confidence interval (CI) 0.39-1.17). For pregnancies exposed to valproate, (0.39, 95% CI 0.20-0.89) lower (7.26%) than (17.9%); difference did not depend on valproate dosage. values significantly different when involved. Logistic regression suggested that coadministration lamotrigine may have reduced valproate. Discussion: hazard more degree fact per se. Coadministration therapy.
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