Teratogenesis in repeated pregnancies in antiepileptic drug-treated women.

摘要: Purpose: Considerable information is now available concerning the risk of teratogenesis in individual pregnancy exposed to antiepileptic drugs (AEDs). However, there comparatively little subsequent pregnancies women who continue take AED associated with a fetal malformation previous pregnancy. This article addresses this matter. Methods: Analysis data abnormalities 1,243 had 2,637 between mid-1999 and 2010 recorded Australian Register Antiepileptic Drugs Pregnancy. Of pregnancies, 1,114 been completed before initial enrolment Register. Key Findings: Women taking any given birth malformed baby their first enrolled same drug were at increased having offspring next (35.7% vs. 3.1%; odds ratio [OR] 17.6; 95% confidence interval [95% CI] 4.5-68.7). Among these women, those valproate (VPA) more likely have fetuses than taken VPA without (57.2% 7.0%, OR 17.8; CI 2.7, 119.1). There similar although not statistically significant trends AEDs other VPA. Similar, again significant, found, when considering pairings most recent preenrollment following one. If woman two or that resulted AED-associated malformation, types often different. Significance: whose last substantially further if they become pregnant while AED, particularly suggests maternal factors, perhaps genomic, predispose least VPA-associated malformations. knowledge, together about outcome pregnancy, should help advising AED-treated epilepsy plan pregnancies.