RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defence

摘要: RNA silencing is a central regulator of gene expression in most eukaryotes and acts both at the transcriptional level through DNA methylation post-transcriptional direct mRNA interference mediated by small RNAs. In plants invertebrates, same pathways also function directly host defence against viruses targeting viral for degradation. Successful have consequently evolved diverse mechanisms to avoid silencing, notably suppressors silencing. been recently identified plant pathogenic bacteria oomycetes, suggesting that disruption general virulence strategy across several kingdoms pathogens. There increasing evidence specific defences RNA-silencing suppression pathogens, providing yet another illustration never-ending molecular arms race between pathogens their hosts.