Recent advances and future trends in the targeted therapy of metastatic gastric cancer
作者： Salah-Eddin Al-Batran , Dominique Werner
DOI: 10.1586/17474124.2014.902304
关键词:
摘要: The better understanding of the molecular mechanisms behind gastric cancer has led to development new therapeutic strategies that are likely improve patient outcomes in near future. Recently, targeting HER2 and VEGF pathways with trastuzumab ramucirumab, respectively, have been found survival, while directed therapies against a number other under clinical evaluation. These include hepatocyte growth factor its receptor c-MET, insulin-like 1, fibroblast factor, mammalian target rapamycin (mTOR), epidermal receptor, pathways, as well relevant immunotherapeutic strategies. This article reviews recent advances future trends these concepts for adenocarcinoma gastroesophageal junction.
informahealthcare.com参考文章(123)
Thun Mj, Calle Ee, Namboodiri Mm, Flanders Wd, Heath Cw, Aspirin Use and Risk of Fatal Cancer Cancer Research. ,vol. 53, pp. 1322- 1327 ,(1993)
Hisato Kawakami, Isamu Okamoto, Tokuzo Arao, Wataru Okamoto, Kazuko Matsumoto, Hirokazu Taniguchi, Kiyoko Kuwata, Haruka Yamaguchi, Kazuto Nishio, Kazuhiko Nakagawa, Yasuhide Yamada, MET amplification as a potential therapeutic target in gastric cancer. Oncotarget. ,vol. 4, pp. 9- 17 ,(2013) , 10.18632/ONCOTARGET.718
Wilko Weichert, Andrea Ullrich, Mathias Schmidt, Volker Gekeler, Aurelia Noske, Silvia Niesporek, Ann-Christin Buckendahl, Manfred Dietel, Carsten Denkert, Expression patterns of polo-like kinase 1 in human gastric cancer. Cancer Science. ,vol. 97, pp. 271- 276 ,(2006) , 10.1111/J.1349-7006.2006.00170.X
G Carpenter, S Cohen, Epidermal growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 7709- 7712 ,(1972) , 10.1016/S0021-9258(19)38983-5
B Schuell, T Gruenberger, W Scheithauer, Ch Zielinski, F Wrba, HER 2/neu protein expression in colorectal cancer. BMC Cancer. ,vol. 6, pp. 123- 123 ,(2006) , 10.1186/1471-2407-6-123
Manish A. Shah, Derek G. Power, Hedy L. Kindler, Kyle D. Holen, Margaret M. Kemeny, David H. Ilson, Laura Tang, Marinela Capanu, John J. Wright, David P. Kelsen, A multicenter, phase II study of Bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma Investigational New Drugs. ,vol. 29, pp. 1475- 1481 ,(2011) , 10.1007/S10637-010-9474-7
S. J. McKenzie, K. A. Desombre, B. S. Bast, D. R. Hollis, R. S. Whitaker, A. Berchuck, C. M. Boyer, R. C. Bast, Serum levels of HER-2neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer Cancer. ,vol. 71, pp. 3942- 3946 ,(1993) , 10.1002/1097-0142(19930615)71:12<3942::AID-CNCR2820711224>3.0.CO;2-3
T. Iveson, R.C. Donehower, I. Davidenko, S. Tjulandin, A. Deptala, M. Harrison, E. Loh, Y. Jiang, K. Oliner, S. Dubey, 6504 ORAL Safety and Efficacy of Epirubicin, Cisplatin, and Capecitabine (ECX) Plus Rilotumumab (R) as First-line Treatment for Unresectable Locally Advanced (LA) or Metastatic (M) Gastric or Esophagogastric Junction (EGJ) Adenocarcinoma European Journal of Cancer. ,vol. 47, pp. S443- ,(2011) , 10.1016/S0959-8049(11)71815-9
David Zaridze, Elena Borisova, Dimitri Maximovitch, Vladimir Chkhikvadze, Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. International Journal of Cancer. ,vol. 82, pp. 473- 476 ,(1999) , 10.1002/(SICI)1097-0215(19990812)82:4<473::AID-IJC1>3.0.CO;2-K
Ibrahim Halil Sahin, Manal M. Hassan, Christopher R. Garrett, Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: Current state-of-the science Cancer Letters. ,vol. 345, pp. 249- 257 ,(2014) , 10.1016/J.CANLET.2013.09.001