Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: Current state-of-the science
作者： Ibrahim Halil Sahin , Manal M. Hassan , Christopher R. Garrett
DOI: 10.1016/J.CANLET.2013.09.001
关键词:
摘要: Abstract Growing evidence from epidemiologic and preclinical studies suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, colorectal cancer, hepatocellular carcinoma. However, there is also indicating absence this benefit. The exact mechanism NSAIDs’ action on GI tumors not known. Although some have suggested inhibition carcinogenesis by NSAIDs through suppression effect inflammation-associated cyclooxygenase-2 (COX-2) expression, other COX-2-independent mechanisms. Herein, we summarize current state of-the-science regarding NSAID benefit for patients with cancers.
elsevier.com
sci-hub.se 参考文章(134)
Seigou Abiru, Kazuhiko Nakao, Tatsuki Ichikawa, Kiyoshi Migita, Masaya Shigeno, Miyuki Sakamoto, Hiroki Ishikawa, Keisuke Hamasaki, Keisuke Nakata, Katsumi Eguchi, Aspirin and NS-398 inhibit hepatocyte growth factor–induced invasiveness of human hepatoma cells Hepatology. ,vol. 35, pp. 1117- 1124 ,(2002) , 10.1053/JHEP.2002.32676
Paul P. Tak, Gary S. Firestein, NF-κB: a key role in inflammatory diseases Journal of Clinical Investigation. ,vol. 107, pp. 7- 11 ,(2001) , 10.1172/JCI11830
Andrew T Chan, Shuji Ogino, Charles S Fuchs, Aspirin Use and Survival After Diagnosis of Colorectal Cancer JAMA. ,vol. 302, pp. 649- 658 ,(2009) , 10.1001/JAMA.2009.1112
Edward Giovannucci, Eric B Rimm, Meir J Stampfer, Graham A Colditz, Alberto Ascherio, Walter C Willett, Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals Annals of Internal Medicine. ,vol. 121, pp. 241- 246 ,(1994) , 10.7326/0003-4819-121-4-199408150-00001
Martin J. Heslin, Ashley Hawkins, William Boedefeld, J Pablo Arnoletti, Andrey Frolov, Richie Soong, Marshall M. Urist, Kirby I. Bland, Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer. Annals of Surgery. ,vol. 241, pp. 941- 947 ,(2005) , 10.1097/01.SLA.0000164177.95620.C1
Hitoshi Sawaoka, Sunao Kawano, Shingo Tsuji, Masahiko Tsujii, Hiroaki Murata, Masatsugu Hori, Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. Journal of Clinical Gastroenterology. ,vol. 27, pp. 47- 52 ,(1998) , 10.1097/00004836-199800001-00009
Nengtai Ouyang, Jennie L. Williams, George J. Tsioulias, Jianjun Gao, Michael J. Iatropoulos, Levy Kopelovich, Khosrow Kashfi, Basil Rigas, Nitric Oxide–Donating Aspirin Prevents Pancreatic Cancer in a Hamster Tumor Model Cancer Research. ,vol. 66, pp. 4503- 4511 ,(2006) , 10.1158/0008-5472.CAN-05-3118
Wenjing Tian, Yashuang Zhao, Shengyuan Liu, Xin Li, Meta-analysis on the relationship between nonsteroidal anti-inflammatory drug use and gastric cancer European Journal of Cancer Prevention. ,vol. 19, pp. 288- 298 ,(2010) , 10.1097/CEJ.0B013E328339648C
Piers A. Gatenby, James R. Ramus, Christine P. Caygill, Marc C. Winslet, Anthony Watson, Aspirin is not chemoprotective for Barrett's adenocarcinoma of the oesophagus in multicentre cohort. European Journal of Cancer Prevention. ,vol. 18, pp. 381- 384 ,(2009) , 10.1097/CEJ.0B013E32832E0955
Tomislav Dragovich, Howard Burris, Patrick Loehrer, Daniel D. Von Hoff, Sherry Chow, Steven Stratton, Sylvan Green, Yrma Obregon, Irene Alvarez, Michael Gordon, Gemcitabine plus celecoxib in patients with advanced or metastatic pancreatic adenocarcinoma: results of a phase II trial. American Journal of Clinical Oncology. ,vol. 31, pp. 157- 162 ,(2008) , 10.1097/COC.0B013E31815878C9