Measurement of thermal effects on the optical properties of prostate tissue at wavelengths of 1,064 and 633 nm.

摘要: Background and Objective The extent of thermal injury during laser prostatectomy is dependent on the light distribution in laser-irradiated tissue. As tissue irradiated, optical properties change as a function temperature due to an alteration molecular cellular structure. The purpose present study was determine how exposure both fresh previously frozen canine prostate elevated temperatures affects properties. Study Design/Materials Methods Optical were measured by using double integrating sphere spectrophotometer with inverse adding-doubling algorithm. Measurements made at two wavelengths (1,064 nm 633 nm) samples heated waterbath 5°–10° increments for 10 min through 50°C range. Results Upon coagulation, absorption coefficient decreased from baseline measurement (0.027 ± 0.003 0.019 0.002 λ = 1,064 nm; 0.073 0.007 0.061 0.006 nm). However, scattering increased sharply following coagulation (3.06 0.26 6.05 0.29 4.89 0.23 7.22 0.30 Thermal occurred between 60°C 70°C. Conclusion Data obtained this indicate that alters properties. which these changes occur found be wavelength freshness These results are significant because they suggest thermally induced may limit depth penetration thus compromising treatment. Lasers Surg. Med. 24:38–47, 1999. © 1999 Wiley-Liss, Inc.