Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens.
作者： Miquel Martin , Billy T Chen , F Woodward Hopf , M Scott Bowers , Antonello Bonci
DOI: 10.1038/NN1713
关键词:
摘要: The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression (LTD) both structures after 1 d abstinence. However, 21 abstinence, LTD was abolished exclusively self-administering rats, suggesting voluntary induced long-lasting neuroadaptations could underlie drug-seeking behavior relapse.
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Mark J. Thomas, Corinne Beurrier, Antonello Bonci, Robert C. Malenka, Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nature Neuroscience. ,vol. 4, pp. 1217- 1223 ,(2001) , 10.1038/NN757
Mark A. Ungless, Jennifer L. Whistler, Robert C. Malenka, Antonello Bonci, Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons Nature. ,vol. 411, pp. 583- 587 ,(2001) , 10.1038/35079077
P.W. Kalivas, N. Volkow, J. Seamans, Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron. ,vol. 45, pp. 647- 650 ,(2005) , 10.1016/J.NEURON.2005.02.005
Michael A. Sutton, Eric F. Schmidt, Kwang-Ho Choi, Christina A. Schad, Kim Whisler, Diana Simmons, David A. Karanian, Lisa M. Monteggia, Rachael L. Neve, David W. Self, Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour Nature. ,vol. 421, pp. 70- 75 ,(2003) , 10.1038/NATURE01249
Tomoko Udo, Francisco Ugalde, Nina DiPietro, HowardB. Eichenbaum, KathleenM. Kantak, Effects of persistent cocaine self-administration on amygdala-dependent and dorsal striatum-dependent learning in rats Psychopharmacology. ,vol. 174, pp. 237- 245 ,(2004) , 10.1007/S00213-003-1734-1
Karen Brebner, Tak Pan Wong, Lidong Liu, Yitao Liu, Paul Campsall, Sarah Gray, Lindsay Phelps, Anthony G Phillips, Yu Tian Wang, Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization Science. ,vol. 310, pp. 1340- 1343 ,(2005) , 10.1126/SCIENCE.1116894
Gregory L. Gerdeman, John G. Partridge, Carl R. Lupica, David M. Lovinger, It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends in Neurosciences. ,vol. 26, pp. 184- 192 ,(2003) , 10.1016/S0166-2236(03)00065-1
R. Christopher Pierce, Vidhya Kumaresan, The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neuroscience & Biobehavioral Reviews. ,vol. 30, pp. 215- 238 ,(2006) , 10.1016/J.NEUBIOREV.2005.04.016
Yavin Shaham, Bruce T Hope, The role of neuroadaptations in relapse to drug seeking. Nature Neuroscience. ,vol. 8, pp. 1437- 1439 ,(2005) , 10.1038/NN1105-1437
Rudolf N. Cardinal, John A. Parkinson, Jeremy Hall, Barry J. Everitt, Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex Neuroscience & Biobehavioral Reviews. ,vol. 26, pp. 321- 352 ,(2002) , 10.1016/S0149-7634(02)00007-6