Animal models of spontaneous pancreatic neuroendocrine tumors.

摘要: Pancreatic neuroendocrine tumors (PNETs) are usually low-grade neoplasms derived from the endocrine pancreas. PNETs can be functioning and cause well-described hormonal hypersecretion syndromes or non-functioning only tumor mass effect. appear to more common recently likely due incidental detection by imaging. Although diagnosis management of have been evolving rapidly, much remains studied in areas molecular pathogenesis, markers behavior, early detection, targeted drug therapy. Unique challenges facing studies long disease course, deep location pancreas difficult access pancreatic tissue, variety tumors, which make animal models valuable tools for studies. Existing provided insights into pathogenesis natural history human PNETs. Future on should address novel therapies.