The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men

摘要: Measurement of serum testosterone (T) levels is recommended in the evaluation osteoporosis older men and estradiol (E2) sex hormone binding globulin (SHBG) are associated with rate bone loss fractures, but clinical utility steroid SHBG measurements for has not been examined. To evaluate whether T, E2, and/or useful prediction fracture risk or men, we analyzed longitudinal data from 5487 community-based participating Osteoporotic Fractures Men (MrOS) study United States, Sweden, Hong Kong. Serum were assessed at baseline; incident fractures self-reported 4-month intervals radiographic verification (US), ascertained via national health records (Sweden, Kong). Rate was by serial measures hip mineral density (BMD). We used receiver operating characteristic (ROC) curves, net reclassification improvement (NRI), integrated discrimination (IDI) to assess prediction. Mean age baseline 72 75 years prevalence low T ( 59.1 nM), neither steroids nor provided clinically discrimination. Similarly, they did contribute BMD change. In conclusion, there limited elderly men. © 2016 American Society Bone Mineral Research.