Niacin for Stroke Prevention: Evidence and Rationale

摘要: Low levels of high-density lipoprotein (HDL) cholesterol are associated with increased atherothrombotic events, including stroke. Niacin is a safe and effective means raising HDL, yet its role in stroke prevention not well characterized. The purpose the study to determine niacin prevention. A search PUBMED database using keywords niacin, stroke, atherosclerosis, and/or carotid artery was undertaken identify studies for review. National guidelines from American Heart Asssociation Cholesterol Education Program were reviewed. Treatment low serum HDL (<40 mg/dL) an identified goal dyslipidemic therapy. reducing cardiovascular events individuals high vascular risk can be used treatment patients HDL. safely combination statins, first-line secondary reduction, efficacy. Studies needed better define extended-release (ER) alone or should considered atherosclerotic mechanisms HDL-C levels.