Effects of the beta-adrenoceptor blocker nipradilol on renal microcirculation in a rat model: A comparative study with propranolol
作者： Kenjiro Kimura , Naoe Suzuki , Naobumi Mise , Shigeyoshi Ohba , Kazuhisa Miyashita
DOI: 10.1016/S0011-393X(98)85014-5
关键词:
摘要: Abstract The objective of the present study was to compare effects vasodilating nonselective beta-adrenoceptor blocker nipradilol on renal microvasculature with those occurring propranolol, a typical blocker. Hydronephrosis induced by ligation left ureter in seventeen 8-week-old stroke-prone, spontaneously hypertensive rats. experiment performed 2 months after surgery. hydronephrotic kidney split longitudinally and spread out as thin sheet, observed directly under light microscope. Intravenous administration 200 μg/kg bolus caused significant decrease systolic blood pressure (−36 mm Hg) at 5 minutes. afferent arteriole significantly dilated transiently (+13% diameter) 10 changes efferent were not statistically significant. glomerular flow increased (+22%) propranolol 600 did cause pressure, arteriolar diameter, or flow. showed constriction (−16% 20 In summary, despite pressure. This effect propranolol.
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