Nipradilol inhibits rat mesangial cell mitogenesis through the activation of soluble guanylate cyclase.
作者： Daisuke Koya , Ryuichi Kikkawa , Masakazu Haneda , Takasi Uzu , Masashi Sawada
DOI: 10.1016/0922-4106(93)90173-7
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摘要: Abstract Nipradilol is a s-adrenoreceptor blocking agent, whose structure contains an NO2 group. Thus, it possible that modulates the function of glomerular mesangial cells through activation soluble guanylate cyclase. To prove this hypothesis, we examined effect nipradilol on cyclase, intracellular cyclic guanosine monophosphate (cGMP) accumulation, and mitogenesis cultured rat cells. increased cGMP accumulation in dose-dependent manner Furthermore, inhibited incorporation [3H]thymidine into stimulated by 2.5% fetal bovine serum manner. These results indicate may modulate cell increase resulting from
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sci-hub.se 参考文章(7)
P. C. Singhal, S. DeCandido, J. A. Satriano, D. Schlondorff, R. M. Hays, Atrial natriuretic peptide and nitroprusside cause relaxation of cultured rat mesangial cells. American Journal of Physiology-cell Physiology. ,vol. 257, ,(1989) , 10.1152/AJPCELL.1989.257.1.C86
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Dennis A. Ausiello, Jeffrey I. Kreisberg, Christian Roy, Morris J. Karnovsky, Contraction of Cultured Rat Glomerular Cells of Apparent Mesangial Origin after Stimulation with Angiotensin II and Arginine Vasopressin Journal of Clinical Investigation. ,vol. 65, pp. 754- 760 ,(1980) , 10.1172/JCI109723
Masakazu Haneda, Ryuichi Kikkawa, Masaki Togawa, Daisuke Koya, Nobuyuki Kajiwara, Yukio Shigeta, Metabolic actions of insulin-like growth factor I in cultured glomerular mesangial cells Metabolism-clinical and Experimental. ,vol. 40, pp. 1311- 1316 ,(1991) , 10.1016/0026-0495(91)90034-T
Masakazu Haneda, Ryuichi Kikkawa, Shiro Maeda, Masaki Togawa, Daisuke Koya, Naoki Horide, Nobuyuki Kajiwara, Yukio Shigeta, Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation Kidney International. ,vol. 40, pp. 188- 194 ,(1991) , 10.1038/KI.1991.199
R. Kikkawa, K. Umemura, M. Haneda, T. Arimura, K. Ebata, Y. Shigeta, Evidence for Existence of Polyol Pathway in Cultured Rat Mesangial Cells Diabetes. ,vol. 36, pp. 240- 243 ,(1987) , 10.2337/DIAB.36.2.240
Shimizu S, Uchida Y, Shirasawa Y, Fujii M, Nakamura M, Vasoactive and beta-adrenoceptor blocking properties of 3,4-dihydro-8-(2-hydroxy-3-isopropylamino) propoxy-3-nitroxy-2H-1-benzopyran (K-351), a new antihypertensive agent. Archives internationales de pharmacodynamie et de thérapie. ,vol. 262, pp. 132- 149 ,(1983)