Alteration of lymphoid cells in AKR mice by treatment with monoclonal antibody against Thy-1 antigen.

摘要: AKR/J mice treated with high levels of monoclonal anti-Thy-1.1 antibody and C' remained healthy without apparent side effects. Examination the lymphatic organs these demonstrated a selective depletion T cells in lymph nodes spleen. Following cessation treatment circulation fell peripheral gradually became repopulated cells. Depletion occurred whether or not was infused along antibody. Although thymocytes were coated they eliminated by treatment. The elimination but thymic suggests either barrier to penetration cofactors (possibly antibody-dependent effector cells) that acts interfering normal traffic which normally "home"