What Can We Learn from Flies: Epigenetic Mechanisms Regulating Blood Cell Development in Drosophila
作者： Paul Badenhorst
DOI: 10.1007/978-3-642-45198-0_2
关键词:
摘要: Drosophila (fruit flies) possess a highly effective innate immune system that provides defence against pathogens include bacteria, fungi and parasites. Pathogens are neutralised by mechanisms phagocytosis, encapsulation melanisation. Circulating cells called haemocytes key component of the resemble granulocyte–macrophage lineages mammals. The regulate haematopoietic progenitor specification differentiation conserved, allowing to be used as useful model understand transcriptional regulation haematopoiesis. In this review I will summarise mesodermal origin haemocyte precursors describe parallels with mammalian haemangioblast precursors. discuss signalling pathways transcription factors three principal cell types. There significant circuitry controls haematopoiesis, such GATA factors, RUNX family members STAT proteins influencing haemocytes. These recruit co-repressor or co-activator complexes alter chromatin structure gene expression. how compartment has been explore function ATP-dependent remodelling histone modifying complexes. As regulators haematopoiesis great genetic amenability offers powerful dissect leukaemogenic fusion RUNX1-ETO. final section use screens identify novel RUNX1-ETO interacting discussed.
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