Nanoparticle functionalization for brain targeting drug delivery and diagnostic

摘要: Nanobiotechnology has been demonstrated to be an efficient tool for targeted therapy as well diagnosis, with particular emphasis on brain tumor and neurodegenerative diseases. On this regard, the aim of chapter is focused M.J. Gomes INEB, Institute Biomedical Engineering, University Porto, Portugal B. Mendes Faculty S. Martins Department Physics, Chemistry Pharmacy, Southern Denmark, Odense, Denmark Sarmento (*) IINFACTS, Pharmaceutical Sciences, Instituto Superior de Ciencias da Saude-Norte, Gandra, e-mail: Bruno.sarmento@ineb.up.pt # Springer International Publishing Switzerland 2016 M. Aliofkhazraei (ed.), Handbook Nanoparticles, DOI 10.1007/978-3-319-15338-4_42 941 engineered nanoparticles brain, so that they have ability overcome blood–brain barrier (BBB) enter tissue. Firstly, it highlighted difficulty physically active molecules colloidal carriers BBB, which impediment treatment several diseases; then, use advantageous cross BBB achieve their functionalization strategies are described; finally delivery target moiety, diagnostics or therapeutics. Therefore, how nanoparticle surface may functionalized drug diagnostics. Furthermore, also mentioned some targets were already used transport mediators central nervous system by nanoparticles. It summarizes potential in therapeutics molecular targeting approach nanoparticle-mediated across where take advantage physiological receptor-mediated processes.