17-β-Estradiol Induces Heat Shock Proteins in Brain Arteries and Potentiates Ischemic Heat Shock Protein Induction in Glia and Neurons

摘要: Estradiol reduces brain injury from many diseases, including stroke and trauma. To investigate the molecular mechanisms of this protection, effects 17-β-estradiol on heat shock protein (HSP) expression were studied in normal male female rats gerbils after global ischemia. 17-β-Estradiol was given intraperitoneally (46 or 460 ng/kg, 4.6 μg/kg) Western blots performed for HSPs. increased hemeoxygenase-1, HSP25/27, HSP70 rats. Six hours administration 17-β-estradiol, hemeoxygenase-1 3.9-fold (460 ng/kg) 5.4-fold (4.6 μg/kg), HSP25/27 2.1-fold Hsp70 2.3-fold ng/kg). Immunocytochemistry showed that HSP25/27,and induction localized to cerebral arteries rats, possibly vascular smooth muscle cells. injected 20 minutes before transient occlusion both carotids adult gerbils. aft...