Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis.
作者： Rodnei Dennis Rossoni , Marisol dos Santos Velloso , Lívia Mara Alves Figueiredo , Carolina Pistille Martins , Antonio Olavo Cardoso Jorge
DOI: 10.1007/S12223-017-0569-9
关键词:
摘要: Candida albicans is the most common human fungal pathogen and can grow as yeast or filaments, depending on environmental conditions. The filamentous form of particular interest because it play a direct role in adherence pathogenicity. Therefore, purpose this study was to evaluate effects three clinical strains Lactobacillus C. filamentation well their probiotic potential pathogen-host interactions via an experimental candidiasis model Galleria mellonella. We used reference strain ATCC 18804 Lactobacillus: L. rhamnosus 5.2, paracasei 20.3, fermentum 20.4. First, capacity hyphae tested vitro through association with strains. After that, we verified ability these attenuate mellonella survival curve assay. Regarding assay, significant reduction formation up 57% observed when incubated presence strains, compared control group composed only albicans. In addition, larvae were pretreated spp. prior infection, rate G. mellonela increased all groups. concluded that influences growth expression virulence factors, which may interfere pathogenicity microorganisms.
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