The Nonlinear Potency of Sub-MAC Concentrations in Nitrous Oxide in Decreasing the Anesthetic Requirement of Enflurane, Halothane, and Isoflurane in Rats

摘要: The effect of nitrous oxide (N2O) on the MAC enflurane, halothane, and isoflurane was determined in male rats. Each rat received either or isoflurane, along with 0%, 15%, 75% N2O. Anesthetic equilibration verified by mass spectrometry sampling end-tidal gases. at each N2O concentration standard tail clamp method. dose-response data for animal were fit a second-order polynomial equation to estimate value coefficient. A linear would result zero, whereas extent which deviate from nonlinearity be reflected an increase this null hypothesis, that coefficient should tested one-sample two-tailed t test. volatile anesthetic requirement decreased as increased; however, it did not do so linearly. For three groups, coefficients consistently greater than zero (P less 0.05). These are consistent accepted presumption summation anesthetics is linear.