Comparison of ethanol concentrations in venous blood and end-expired breath during a controlled drinking study

摘要: Concentration-time profiles of ethanol were determined for venous whole blood and end-expired breath during a controlled drinking experiment in which healthy men (n=9) women drank 0.40-0.65 g per kg body weight 20-30 min. Specimens obtained analysis starting at 50-60 min post-dosing then every 30-60 3-6 h. This protocol furnished 130 blood-breath pairs statistical evaluation. Blood-ethanol concentration (BAC, mg/g) was by headspace gas chromatography breath-ethanol (BrAC, mg/2l) with quantitative infrared analyzer (Intoxilyzer 5000S), is the instrument currently used Sweden legal purposes. In 18 instances Intoxilyzer 5000S gave readings 0.00 mg/2l whereas actual BAC 0.08 mg/g on average (range 0.04-0.15 mg/g). The remaining 112 blood- breath-alcohol measurements highly correlated (r=0.97) regression relationship BAC=0.10+0.91BrAC residual standard deviation (S.D.) 0.042 (8.4%). slope (0.91+/-0.0217) differed significantly from unity being 9% low intercept (0.10+/-0.0101) deviated zero (t=10.2, P 0.05). mean rate disappearance 0.157+/-0.021 mg/(g hour), very close to elimination 0.161+/-0.021 mg/(2l hour) (P>0.05). Breath-test results (mg/2l) generally less than coexisting concentrations (mg/g), gives an advantage suspect who provides compared cases threshold alcohol limit.