The Photoreceptor Connecting Cilium A Model for the Transition Zone

摘要: Vertebrate photoreceptors provide an excellent system for investigating the organization and maintenance of membrane domains cell polarity necessary sensory function. In particular, connecting cilium appears to play important role in photoreceptor organization. This specialized region corresponds structurally transition zone motile cilia. As a consequence, studies structure function are likely insight into cilia found more generally eukaryotic cells. The purpose this chapter is review our current understanding both with emphasis on features that it may share other principal focus recent research generation polarized photoreceptors. Details many advances development, molecular biology, transduction, turnover beyond scope chapter, but discussed series reviews (Papermaster Schneider, 1982; Bok, 1985; Besharse, 1982, 1986; Besharse et al., 1988; Liebman, 1987; Applebury Hargrave, Adler, 1986).