Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen

摘要: We studied the clinical outcomes of 171 adults with hematologic malignancies who received unrelated cord blood transplantation (CBT) as a primary stem-cell source (n 100), or bone marrow transplant (BMT) peripheral (PBSCT) from related donors 71, 55 BMT and 16 PBSCT). All patients myeloablative regimens including 12 Gy total body irradiation. analyzed recovery, risks graft-versus-host disease (GVHD), transplantation-related mortality (TRM) relapse, diseasefree survival (DFS) using Cox proportional hazards models. Significant delays in engraftment occurred after transplantation; however, overall rates were almost same for both grafts. The cumulative incidences grades III to IV acute extensive-type chronic GVHDs among CBT recipients significantly lower than those BMT/PBSCT recipients. Multivariate analysis demonstrated no apparent differences TRM (9% 13% recipients), relapse (17% 26% DFS (70% 60% BMT/ PBSCT recipients) between groups. These data suggest that could be safe effective mobilized adult when it is used source. (Blood. 2007; 109:1322-1330)