Depression, Sleep Disorders, and DA

作者: Traci J. Speed , Patrick H. Finan

DOI: 10.1007/978-3-319-46437-4_9

关键词:

摘要: Sleep is the quintessential circadian behavior, driven by homeostatic and environmental forces, essential for survival. Disruption of rhythms leads to numerous metabolic, cardiovascular, neuropsychiatric diseases. Depression displays its own rhythmic pattern with recurrent episodes frequently cues including poor sleep. Insomnia, defined as difficulty initiating or maintaining sleep non-restorative that causes significant daytime impairment, affects majority individuals depression. Insomnia symptoms persist even after remission from affective disturbances are risk factors recurrence clinical outcomes. Research has demonstrated a bidirectional longitudinal relationship between insomnia depressive disorders, however exact mechanisms underlying these associations remain unknown. The evidence implicates dopamine neurobiological factor associated Dopamine neuromodulator regulates reward processing, arousal states, affect, mood regulation. However, putative role in depression largely been underappreciated understudied. Indeed, elucidating common dopaminergic pathways linking disorders may shed light on development progression both provide targets interventions. It reasonable glean this chapter alteration mesolimbic signaling pathway underlies comorbidity depression, insomnia, rhythm disorders. In present chapter, our goals (a) brief overview wake, focus architecture; (b) describe depression; (c) discuss possible implications architecture-mediated changes (d) circadian-mediated

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