Use of the mitotic counts for the prognosis and grading of breast cancer. Method evaluation study.

摘要: Summary Reproducibility of the volume fraction-corrected mitotic index (M/V V index) was studied in 144 unselected breast cancer specimens. The influence on decision making variation determining also analyzed. — In complete series specimens correlation between two observers, one subjectively estimating epithelial fraction tumor epithelium and other using point-counting (10 × 10 ocular grid), good (Pearson's r = 0.82, p method. mean grading efficiency as estimated from this subset varied 90% 93%. average minimum GE value 82.8% (SD 3.4%). findings suggest that when M/V method is used, correct or more cases, but dependant cutoff point. over-all at least 85% all cutpoints both series. GE-value comparable to obtained published S-phase data three independed laboratories. We conclude analysis a sufficiently reproducible mitosis counting, it can be used with subjective point count estimation area neoplastic epithelium.