TLR SIGNALING PATHWAYS

作者: Kiyoshi Takeda , Shizuo Akira

DOI: 10.1016/J.SMIM.2003.10.003

关键词:

摘要: … substitution to histidine caused a dominant negative effect on TLR-mediated signaling [6], [7]. In the signaling pathway downstream of the TIR domain, a TIR domain-containing adaptor, …

参考文章(53)
Ruslan Medzhitov, Paula Preston-Hurlburt, Charles A. Janeway, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature. ,vol. 388, pp. 394- 397 ,(1997) , 10.1038/41131
Kimberly Burns, Jonathan Clatworthy, Laurence Martin, Fabio Martinon, Chris Plumpton, Barbara Maschera, Alan Lewis, Keith Ray, Jürg Tschopp, Filippo Volpe, Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor Nature Cell Biology. ,vol. 2, pp. 346- 351 ,(2000) , 10.1038/35014038
Fumitaka Hayashi, Kelly D. Smith, Adrian Ozinsky, Thomas R. Hawn, Eugene C. Yi, David R. Goodlett, Jimmy K. Eng, Shizuo Akira, David M. Underhill, Alan Aderem, The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. ,vol. 410, pp. 1099- 1103 ,(2001) , 10.1038/35074106
Tiffany Horng, Gregory M. Barton, Ruslan Medzhitov, TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunology. ,vol. 2, pp. 835- 841 ,(2001) , 10.1038/NI0901-835
Chen Wang, Li Deng, Mei Hong, Giridhar R Akkaraju, Jun-ichiro Inoue, Zhijian J Chen, None, TAK1 is a ubiquitin-dependent kinase of MKK and IKK Nature. ,vol. 412, pp. 346- 351 ,(2001) , 10.1038/35085597
David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar, Anne Stevens, Christopher B. Wilson, Michael Bassetti, Alan Aderem, The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens Nature. ,vol. 401, pp. 811- 815 ,(1999) , 10.1038/44605
Shizuo Akira, Kiyoshi Takeda, Tsuneyasu Kaisho, Toll-like receptors: critical proteins linking innate and acquired immunity Nature Immunology. ,vol. 2, pp. 675- 680 ,(2001) , 10.1038/90609
Katherine A. Fitzgerald, Eva M. Palsson-McDermott, Andrew G. Bowie, Caroline A. Jefferies, Ashley S. Mansell, Gareth Brady, Elizabeth Brint, Aisling Dunne, Pearl Gray, Mary T. Harte, Diane McMurray, Dirk E. Smith, John E. Sims, Timothy A. Bird, Luke A. J. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature. ,vol. 413, pp. 78- 83 ,(2001) , 10.1038/35092578
Tiffany Horng, Gregory M. Barton, Richard A. Flavell, Ruslan Medzhitov, The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors Nature. ,vol. 420, pp. 329- 333 ,(2002) , 10.1038/NATURE01180