Pursuit of Personalized Anticancer Therapy: Leveraging Collaboration Between Academia and the Biotech/Pharmaceutical Industry

摘要: Over the past 2 decades, our increased understanding of tumor biology has resulted in delivery a new generation molecularly targeted cancer drugs with greater efficacy and less toxicity. This also provided pharmaceutical academic institutions appreciation for complexities challenges associated discovering developing drugs. To deal technologies needed to develop drugs, there been cooperation collaboration between pharmaceutical-industry researchers broader number aspects drug discovery development continuum, including structural translational research. collaborative effort played role such as cetuximab, trastuzumab, imatinib, promising candidates OSI-906. Cooperative efforts by industry academia have important insights optimize use agents clinic. review aims emphasize need academic/industrial collaborations success efficiency through will highlight several examples industrial scientists that facilitated antitumor into Mt Sinai J Med 77:358–365, 2010. © 2010 Mount School Medicine