Progression of mitral regurgitation: A prospective Doppler echocardiographic study

摘要: OBJECTIVES This study was performed to define the rates and determinants of progression organic mitral regurgitation (MR). BACKGROUND Severe MR has major clinical consequences, but degree are unknown. Quantitative Doppler echocardiographic methods allow quantitation regurgitant volume (RVol), fraction (RF) effective orifice (ERO) MR. METHODS In a prospective progression, 74 patients had two quantitative examinations (with at least methods) 561 ± 423 days apart without an intervening event. RESULTS Progression observed, with increase in RVol (77 46 ml vs. 65 40 ml, p 8 found 11% 51%, respectively. In multivariate analysis, independent predictors were lesions, particularly new flail leaflet (p = 0.0003), annulus diameter 0.0001). Regression associated marked changes afterload, decreased blood pressure 0.008). No significant effect treatment detected. CONCLUSIONS Organic tends progress over time overload (RVol) due ERO. Progression is variable determined by lesions or size. These data should help plan follow up future intervention trials.