Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

摘要: Abstract The occurrence of physiological cell death has been known for decades, but interest in the subject was renewed 1972 when Kerr, Wyllie and Currie described detail ultrastructural changes characteristic dying cells coined term apoptosis to describe process. Cells display a wide variety morphological during development or following toxic insult. A binary classification scheme suggests that physiologically appropriate is due pathological mechanisms involve necrosis. However, recent studies indicate potential involvement apoptotic ischemia, status epilepticus HIV-I infection.