On the biochemical and molecular mechanisms by which malathion induces dysfunction in pancreatic islets in vivo and in vitro

摘要: Abstract Recent studies showed that organophosphorus pesticides can increase incidence of metabolic disorders and diabetes. Considering the importance pancreas in regulating blood glucose, effect malathion on essential elements glucose-stimulated insulin secretion (GSIS) vitro vivo conditions were evaluated. After dividing rats into control treatment groups, oral glucose tolerance test (OGTT) was examined then kinetic as well pancreatic response to raise isolation islets from pancreas, its function oxidative stress markers GSIS examined. Malathion at dose 400 mg/kg impaired GTT increased AUC0–180 min (P = 0.047) T1/2β (P = 0.0016), reduced (P = 0.005) 30 min after administering glucose. In addition tolerance, there significant increases lipid peroxidation (P  Conclusion Dysfunction metabolism impairment are associated with a depletion energy induction following acute exposure malathion.