The new era for the treatment of psoriasis and psoriatic arthritis: Perspectives and validated strategies
作者： Lucia Novelli , Maria Sole Chimenti , Andrea Chiricozzi , Roberto Perricone
DOI: 10.1016/J.AUTREV.2013.08.006
关键词:
摘要: Psoriatic Arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis. Psoriasis (PsO) chronic, skin disease, characterized by hyperproliferation and aberrant differentiation of keratinocytes. PsA PsO can be considered as unique disease are immune-mediated diseases both innate adaptive immunity play role in their pathogenesis. Initially, were thought to Th1-mediated diseases, however, the last years, several studies have shown interleukin 17 (IL-17) Th17 cells pathogenesis PsO. been detected dermal infiltrates psoriatic lesions well synovial fluid. Interleukin (IL)-23, produced antigen presenting (APC), especially dendritic (DC), key regulator cytokine for IL-17 production. In this review we discuss IL-23 therapeutic targets treatment.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(81)
Michael Benjamin, Dennis McGonagle, The Enthesis Organ Concept and Its Relevance to the Spondyloarthropathies Advances in Experimental Medicine and Biology. ,vol. 649, pp. 57- 70 ,(2009) , 10.1007/978-1-4419-0298-6_4
C Perricone, M D Guarino, D Graceffa, E Greco, P Conigliaro, B Kroegler, M S Chimenti, E Ballanti, G Di Muzio, R Perricone, Complement system in psoriatic arthritis: a useful marker in response prediction and monitoring of anti-TNF treatment. Clinical and Experimental Rheumatology. ,vol. 30, pp. 23- 30 ,(2012)
K.A. Papp, R.G. Langley, B. Sigurgeirsson, M. Abe, D.R. Baker, P. Konno, S. Haemmerle, H.J. Thurston, C. Papavassilis, H.B. Richards, Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study British Journal of Dermatology. ,vol. 168, pp. 412- 421 ,(2013) , 10.1111/BJD.12110
Aurélie Ambrosi, Alexander Espinosa, Marie Wahren-Herlenius, IL-17: a new actor in IFN-driven systemic autoimmune diseases. European Journal of Immunology. ,vol. 42, pp. 2274- 2284 ,(2012) , 10.1002/EJI.201242653
W. C. Fanslow, S. L. Painter, Zhengbin Yao, R. J. Armitage, D. Ulrich, B. M. Macduff, M. K. Spriggs, Human IL-17: a novel cytokine derived from T cells. Journal of Immunology. ,vol. 155, pp. 5483- 5486 ,(1995)
Rolf E. Kuestner, David W. Taft, Aaron Haran, Cameron S. Brandt, Ty Brender, Karen Lum, Brandon Harder, Shannon Okada, Craig D. Ostrander, James L. Kreindler, Shean J. Aujla, Brian Reardon, Margaret Moore, Pamela Shea, Randall Schreckhise, Thomas R. Bukowski, Scott Presnell, Patricia Guerra-Lewis, Julia Parrish-Novak, Jeff L. Ellsworth, Stephen Jaspers, Katherine E. Lewis, Mark Appleby, Jay K. Kolls, Mark Rixon, James W. West, Zeren Gao, Steven D. Levin, Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F Journal of Immunology. ,vol. 179, pp. 5462- 5473 ,(2007) , 10.4049/JIMMUNOL.179.8.5462
Robert L. Coffman, Timothy R. Mosmann, Holly Cherwinski, Martin A. Giedlin, Martha W. Bond, Pillars Article: Two Types of Murine Helper T Cell Clone. I. Definition According to Profiles of Lymphokine Activities and Secreted Proteins. J. Immunol., 1986, 136: 2348–2357. Journal of Immunology. ,vol. 175, pp. 5- 14 ,(2005)
Robert L Coffman, Timothy R Mosmann, Martin A Giedlin, Holly Cherwinski, Martha W Bond, Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. Journal of Immunology. ,vol. 136, pp. 2348- 2357 ,(1986)
Newman Yeilding, Philippe Szapary, Carrie Brodmerkel, Jacqueline Benson, Michael Plotnick, Honghui Zhou, Kavitha Goyal, Brad Schenkel, Jill Giles-Komar, Mary Ann Mascelli, Cynthia Guzzo, Development of the IL-12/23 antagonist ustekinumab in psoriasis: past, present, and future perspectives - an update Annals of the New York Academy of Sciences. ,vol. 1263, pp. 1- 12 ,(2012) , 10.1111/J.1749-6632.2012.06670.X
Nicholas R. Telfer, The Role of Streptococcal Infection in the Initiation of Guttate Psoriasis Archives of Dermatology. ,vol. 128, pp. 39- 42 ,(1992) , 10.1001/ARCHDERM.1992.01680110049004