The effect of long-term doxycycline treatment in a mouse model of cigarette smoke-induced emphysema and pulmonary hypertension

Hai-Wei Wu, De-Min Li, Biao Xu, Chang-Tian Wang, Lei Zhang, Lei Wei, Doxycycline attenuates acute lung injury following cardiopulmonary bypass: involvement of matrix metalloproteinases. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 7460- 7468 ,(2014)

Guanmei Wen, Cheng Zhang, Qishan Chen, Le Anh Luong, Arif Mustafa, Shu Ye, Qingzhong Xiao, A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization Journal of Biological Chemistry. ,vol. 290, pp. 19158- 19172 ,(2015) , 10.1074/JBC.M114.634022

Hiroyuki Tsuji, Hitoshi Fujimoto, Kyeonghee Monica Lee, Roger Renne, Asuka Iwanaga, Chigusa Okubo, Saeko Onami, Ayako Koizumi Nomura, Tomoki Nishino, Hiroyuki Yoshimura, Characterization of biochemical, functional and structural changes in mice respiratory organs chronically exposed to cigarette smoke Inhalation Toxicology. ,vol. 27, pp. 342- 353 ,(2015) , 10.3109/08958378.2015.1051248

B.Timothy Baxter, William H. Pearce, Eugene A. Waltke, Fred N. Littooy, John W. Hallett, K.Craig Kent, Gilbert R. Upchurch, Elliot L. Chaikof, Joseph L. Mills, Beverly Fleckten, G.Matt Longo, Jason K. Lee, Robert W. Thompson, Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study. Journal of Vascular Surgery. ,vol. 36, pp. 1- 12 ,(2002) , 10.1067/MVA.2002.125018

Raquel C Antonio, Carla S Ceron, Elen Rizzi, Eduardo B Coelho, Jose E Tanus-Santos, Raquel F Gerlach, None, Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR. Molecular and Cellular Biochemistry. ,vol. 386, pp. 99- 105 ,(2014) , 10.1007/S11010-013-1848-7

S Saveljeva, S L Mc Laughlin, P Vandenabeele, A Samali, M J M Bertrand, Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells Cell Death and Disease. ,vol. 6, ,(2015) , 10.1038/CDDIS.2014.548

A. Kistner, M. Gossen, F. Zimmermann, J. Jerecic, C. Ullmer, H. Lubbert, H. Bujard, Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 10933- 10938 ,(1996) , 10.1073/PNAS.93.20.10933

Varsha V. Gupte, Suresh K. Ramasamy, Raghava Reddy, Jooeun Lee, Paul H. Weinreb, Shelia M. Violette, Andreas Guenther, David Warburton, Barbara Driscoll, Parviz Minoo, Saverio Bellusci, Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. American Journal of Respiratory and Critical Care Medicine. ,vol. 180, pp. 424- 436 ,(2009) , 10.1164/RCCM.200811-1794OC

Jan H.N. Lindeman, Hazem Abdul-Hussien, J. Hajo van Bockel, Ron Wolterbeek, Robert Kleemann, Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells. Circulation. ,vol. 119, pp. 2209- 2216 ,(2009) , 10.1161/CIRCULATIONAHA.108.806505

M Gossen, S Freundlieb, G Bender, G Muller, W Hillen, H Bujard, Transcriptional activation by tetracyclines in mammalian cells Science. ,vol. 268, pp. 1766- 1769 ,(1995) , 10.1126/SCIENCE.7792603