Adenosine A2B Receptors: An Optional Target for the Management of Irritable Bowel Syndrome with Diarrhea?

摘要: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered habits (diarrhea, constipation, or both). IBS highly prevalent condition, which negatively affects quality life significant burden on global healthcare costs. Although many pharmacological medicines have been proposed to treat IBS, including those targeting receptors, channels, chemical mediators related visceral hypersensitivity, successful pharmacotherapy for disease has not established. Visceral hypersensitivity plays an important role in pathogenesis. Immune activation observed diarrhea-predominant patients contributes development hypersensitivity. Adenosine mediator that regulates physiological processes, inflammation nociception. Among its adenosine A2B receptor intestinal secretion, motor function, immune response. We recently demonstrated involved animal models IBS. In this review, we discuss possibility as novel therapeutic target