Thermoregulation with Age: Role of Beta-Adrenergic Signal Transduction

摘要: The predominance of the evidence from our studies indicates that beta 3-adrenergic-mediated thermogenesis in interscapular BAT is impaired with age. Moreover, upon exposure to cold, beta-adrenergic responsiveness restored. However, exact nature 3-adrenergic upregulation unknown. When senescent rats are exposed cold for as a little 1 h, increase GDP binding equal response young rats. This any cold-induced signal transduction pathway must respond within this time frame. employed have been reared throughout their life at or near thermoneutrality. We hypothesize under such conditions, atrophies age, whereas induction pathways components system remain intact. For example, stimulation UCP mRNA maintained thermoneutrality 54% Upon possibly through combination enhanced 3AR-adenylyl cyclase coupling gene expression both, restored rat.